Interestingly, none of these roles have exact character matches from the recent comic runs of Moon Knight. There hasn’t been a main character in the comics associated with Moon Knight who has been both Egyptian and female as described by the “female lead” listing.
The Direct has exclusively obtained a casting call for four new characters in Moon Knight. For all four of these roles, Marvel Studios limiting their casting to only Egyptian actors and actresses.
The first role is intended for a lead female character and is casting an actress who is fairly younger than Oscar Isaac (41).
[FEMALE LEAD] 20s-30s, Egyptian, strong, intelligent and self-sufficient, she’s always two steps ahead
The last three roles are less specific when it comes to the actors’ age and it would seem that they are for supporting characters with less screen time than the female lead role:
CHARACTER 2] Male, All ages, Egyptian, dignified and powerful
The last role listed is open to any gender
[CHARACTER 3] Male/Female, All ages, Egyptian, eccentric with a sharp wit and interesting physicality
It’s possible, though purely speculation, that these four roles could be some of the various Egyptian gods that have relation to Moon Knight. The most prominent being Khonshu, who brings Marc Spector back to life while granting him supernatural abilities to fight evil in his name. Other gods that Spector has encountered include Anubus and Ammut, the latter of which held him captive in a mental hospital within his own mind.